Robert B Dickson

Genes, Oncogenes and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer - Cancer Treatment and Research Robert B Dickson

Marc Notes: Includes bibliographical references and index. Table of Contents: I. The Progression of Node-Negative to -Positive Breast Cancer.- 1. Prognostic Factors in Axillary Node-Negative Breast Cancer.- 2. Role of Type IV Collagenases in Human Breast Cancer.- II. Suppressor Genes and Negative Growth Factors.- 3. Suppressor Genes in Breast Cancer: An Overview.- 4. The Role of the Retinoblastoma Gene in Breast Cancer Development.- 5. Mammary Derived Growth Inhibitor (MDGI).- 6. Roles for Transforming Growth Factors-? in the Genesis, Prevention, and Treatment of Breast Cancer.- III. Oncogenes and Stimulatory Growth Factors.- 7. Mechanisms Involving an Expanding erbB/EGF Receptor Family of Tyrosine Kinases in Human Neoplasia..- 8. c-erbB2 Amplification and Overexpression in Human Tumors.- 9. Clinical Significance of c-erbB2B2 Protein Overexpression.- Anti-p185HER2 Monoclonal Antibodies: Biological Properties and Potential for Immunotherapy193.- 11. A Chimeric EGFR/neu Receptor in Studies of neu Function.- 12. Involvement of Protein Kinase C in the Growth Regulation of Human Breast Cancer Cells.- 13. Tyrosine Kinase Receptor Nuclear Protooncogene Interactions in Breast Cancer.- IV. Steroid Hormone Receptors.- 14. Characterization and Regulation of Estrogen and Progesterone Receptors in Breast Cancer.- 15. Estrogen and Progesterone Receptor Structure and Action in Breast Cancer Cells.- 16. Progesterone Receptors in Breast Cancer.- V. Differentiation and Function of Epithelium and Stroma in the Breast.- 17. Intermediate Filament Protein Expression in Normal and Malignant Human Mammary Epithelial Cells.- 18. Casein Gene Expression: From Transfection to Transgenics.- 19. The Whey Acidic Protein.- 20. Stromal-Epithelial Interactions in Breast Cancer."Publisher Marketing: This volume is the thrid edited by Drs. Dickson and Lippman in the Advances in Cellular and Molecular Biology of Breast Cancer series. It continues to explore the scientific themes begun in the first two volumes: oncogenes and antioncogenes, growth factors, steroids, and stromal-epithelial interactions. Rapid and important progress has continued to take place in all of thse areas, especially the possbility that the new molecular understanding of regulation of growth, differentiation and metastases will lead to better tumour prognosis and treatment. For this reason this volume begins with two excellent chapters in this area.

Contributor Bio:  Dickson, Robert B Dickson, Lombardi Cancer Research Center, Georgetown University, Washington, DC