Elena Poole

Neurodegeneration: Molecular and Cellular Mechanisms Elena Poole

The process of neurodegeneration is a progressive degeneration of neuron cells. It can be categorized into varied levels of neuronal circuitry ranging from molecular to systemic levels. Aging is the primary contributor to neurodegeneration. Neurodegenerative diseases are caused due to genetic mutations. Protein misfolding is another characteristic that is common in such conditions. Intracellular mechanisms such as protein degradation pathways, mitochondrial dysfunction, membrane damage, axonal transport, DNA damage, etc. along with programmed cell death mechanisms are other pathways of neurodegeneration. This book presents researches and studies performed by experts across the globe on the molecular and cellular mechanisms of neurodegeneration. While understanding the long-term perspectives of the topics, this book makes an effort in highlighting its impact as a modern tool for the understanding of neurodegenerative disorders. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.