Pharmacological Preconditioning with Opioids for Myocardial Protection: Role of Delta-opioid Receptor Agonists - Daniel Sigg - Books - LAP LAMBERT Academic Publishing - 9783838353791 - March 30, 2010
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Daniel Sigg
Pharmacological Preconditioning with Opioids for Myocardial Protection: Role of Delta-opioid Receptor Agonists

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The objective of this research was to investigate the role of opioids in myocardial protection of the large mammalian heart. A porcine isolated working heart model of swine was carefully characterized and various opioid agonists were administered prior to inducing global ischemia. An acute coronary occlusion model was developed to investigate the effects of opioid preconditioning on regional ischemia, in particular infarct size, myocardial function, and arrhythmias. The results of these studies suggest a specific role of ?-receptor agonists in myocardial protection in large mammalian hearts.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released March 30, 2010
ISBN13 9783838353791
Publishers LAP LAMBERT Academic Publishing
Pages 208
Dimensions 226 × 12 × 150 mm   ·   328 g
Language German  

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