Sergey Shchelkunov

Biologicheskie Effekty Virusnogo Tnf-svyazyvayushchego Belka: Opisanie I Analiz Eksperimental'nykh Dannykh Sergey Shchelkunov Russian edition

Giperproduktsiya faktora nekroza opukholey (TNF) igraet vedushchuyu rol' v patogeneze vospalitel'nykh zabolevaniy, v tom chisle autoimmunnoy prirody. TNF rassmatrivaetsya kak osnovnaya mishen' pri razrabotke novykh antitsitokinovykh tekhnologiy lecheniya vospalitel'nykh zabolevaniy. V kachestve al'ternativy k sushchestvuyushchim podkhodam s ispol'zovaniem monoklonal'nykh antitel k TNF rassmatrivaetsya eshche odin podkhod ? ispol'zovanie rekombinantnykh virusnykh belkov (v chastnosti, belkov ortopoksvirusov), blokiruyushchikh aktivnost' TNF. K vazhneyshemu faktoru patogennosti virusa natural'noy ospy (VNO) otnosyat gen TNF-svyazyvayushchego belka, kotoryy imeet nebol'shuyu gomologiyu s kletochnym retseptorom TNF, no sushchestvenno men'she ego po razmeru. VNO adaptirovan dlya razmnozheniya i peredachi tol'ko v populyatsii lyudey i vysoko patogenen dlya cheloveka. Predstavleny eksperimental'nye dannye, demonstriruyushchie, chto rekombinantnyy belok VNO ? VARV-CrmB ? yavlyaetsya TNF-svyazyvayushchim belkom, sposobnym otmenyat' ego biologicheskie effekty kak v razlichnykh immunologicheskikh testakh in vitro, tak i v eksperimental'nykh modelyakh. Dlya nauchnykh sotrudnikov, prakticheskikh vrachey, studentov.