Isabelle Godin

Hematopoietic Stem Cell Development - Medical Intelligence Unit Isabelle Godin 2006 edition

Marc Notes: Co-pub. with Kluwer Academic/Plenum Publishers, New York, NY.; Includes bibliographical references and index.; Bibl. ref. & index; Co-pub. with Kluwer Academic/Plenum Publishers, New York, NY. Table of Contents: Preface -- 1. Ventral and Dorsal Contributions to Hematopoiesis in Xenopus / Aldo Ciau-Uitz, Maggie Walmsley, Roger Patient -- Hematopoietic Organs in Xenopus -- Origins of Hematopoietic Cells in Xenopus -- Development of Hematopoietic Cells in Association with Endothelial Cells in Xenopus -- Embryonic Signals Involved in Hematopoietic Development in Xenopus -- 2. Genetic Dissection of Hematopoiesis Using the Zebrafish / Rebecca A. Wingert, Leonard I. Zon -- Zebrafish Hematopoiesis -- Zebrafish Genetics and Hematopoietic Mutants -- Mesoderm Patterning Mutants -- Hematopoietic Stem Cell Mutants -- Committed Progenitor Mutants -- Differentiation and Proliferation Mutants -- Hypochromic Blood Mutants -- Photosensitive Mutants -- Future Directions -- 3. Extra- and Intraembryonic HSC Commitment in the Avian Model / Thierry Jaffredo, Karine Bollerot, Krisztina Minko, Rodolphe Gautier, Stephane Romero, Cecile Drevon -- The HSC That Colonise the Hematopoietic Organs Have an Extrinsic Origin -- The Discovery of an Intraembryonic Hematopoietic Site -- Gastrulation and Patterning of the Mesoderm -- Role of the Endoderm -- Hemangioblast and the Hemogenic Endothelium -- Dual Origin of Aortic ECs -- Manipulating the Angiopoietic/Hemangiopoietic Commitment -- The Allantois, a Later Source of HSC Colonizing the Bone Marrow -- 4. Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem Cell Differentiation / Jussi Liippo, Olli Lassila -- Hemangioblasts -- Transcription Factors and Early Hematopoiesis -- Adoption of the Lymphoid Fate -- Molecular Control of T Lymphopoiesis -- Molecular Control of B Lymphopoiesis -- The Ikaros Family of Transcription Factors -- Contribution of Ikaros to the Hematopoietic Compartments -- Ikaros and Hematopoietic Stem Cells -- Ikaros and Thymocyte Development -- Ikaros: A Threshold for T Cell Function -- Aiolos: Setting Brakes for B Cells -- Ikaros and Aiolos Running the Lymphoid Chromatin Modifying Machinery -- The Ikaros Family in Avian Lymphohematopoiesisp58 -- 5. Yolk Sac Development in Mice / James Palis -- Gastrulation and Yolk Sac Formation -- Blood Island Formation -- Hemangioblast -- Primitive Erythropoiesis -- Development of Unipotential Hematopoietic Progenitors -- Development of Multipotential Myeloid Progenitors -- Development of Hematopoietic Stem Cells -- Summary: A Model of Yolk Sac Hematopoiesis -- 6. Long-Term Reconstituting Hematopoietic Stem Cell Capacity in the Embryo / Mervin C. Yoder -- General Principles of Hematopoietic Stem Cell Emergence during Ontogeny -- Emergence of Hematopoietic Stem Cells in the Yolk Sac -- Hemaropoietic Stem Cell Ontogeny in the Embryo Proper -- 7. The Endothelium: The Cradle of Definitive Hematopoiesis? / Katrin Qttersbach, Elaine Dzierzak -- The Emergence of Definitive HSCs: Origin and Regulation -- Hemangioblast or Hemogenic Endothelial Cells? -- 8. Endothelial and Hematopoietic Cells in the Intraembryonic Compartment / Fumio Arai, Toshio Suda -- Development of Vasculature -- Development of HCs -- Regulation of Hematopoiesis -- Homangioblasts: Common Progenitors of HCs and ECs -- Interaction between HSCs and ECs -- 9. Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo / Julion Yuan Bertrand, Alexandra Manaia, Jeanne Van Celst, Ana Cumano, Isabelle Godin -- Extra- and Intraembryonic Contribution to Hematopoietic Development -- Intraembryonic Hematopoiesis: To the Precise Origin of HSC -- 10. Hematopoietic Development in Drosophila: A Parallel with Vertebrates / Marie Meister, Shubha Govind -- Drosophila Hemocyte Types and Their Functions -- Hematopoietic Development -- Genetic Control of Hematopoiesis -- Hormonal Control of Hematopoiesis -- Drosophila as a Model System for Understanding Mammalian Hematopoiesis -- 11. Intraembryonic Development of Hematopoietic Stem Cells during Human Ontogeny: Expression. Analysis / Caroline Marshall -- Techniques -- Analysis of Gene Expression Patterns in the Human AGM -- Expression of Receptors and Ligands in the Human AGM -- Expression of Transcription Factors in the AGM -- Expression of Cell Adhesion Molecules in the AGM -- Environmental Expression Patterns in the AGM -- Comparison of AGM and Fetal Liver Expression Patterns -- 12. Gene and Cell Therapy Involving Hematopoietic Stem Cell / Isabelle Andri-Schmutz, Marina Cavazzana-Calvo -- Hematopoietic Stem Cell Transplantation (HSCT): Generalities -- Gene Therapy -- Severe Combined Immunodeficiency Disease -- Fanconi Anemia -- Chronic Granulomatous Disease -- Hemoglobinopathies -- Conclusions and Perspectives in the Use of HSC for Regenerative Medicine -- Index