Uwe Lendeckel

Proteases in the Brain - Proteases in Biology and Disease Uwe Lendeckel 2005 edition

Marc Notes: Includes bibliographical references and index. Table of Contents: Chapter 1 Proteases and Alzheimer Disease: Present Knowledge and Emerging Concepts of Therapy Hans-Gert Bernstein Chapter 2 Calpain Proteolysis and the Etiology of Parkinson s Disease: An Emerging Hypothesis Stephen J. Crocker, Patrice D. Smith and David S. Park Chapter 3 Cysteine Proteases in Neuronal Death in Brain Ischemia Swapan K. Ray Chapter 4 Proteases in Traumatic Brain Injury Susan M. Knoblach and Alan I. Faden Chapter 5 Proteases in CNS Infection and Inflammation Bernd C. Kieseier and Fabian Bernal Chapter 6 Dipeptidyl Peptidase IV Regulates T Cell Function in CNS Inflammation Stefan Brocke, Andreas Steinbrecher, Aliza Biton, Maya Ratner, Vera Preller, Bettina Rotthauwe, Sabine Wrenger and Dirk Reinhold Chapter 7 Role and Regulation of Proteases in Human Glioma Sajani S. Lakka and Jasti S. Rao Chapter 8 Proteases and Prion Diseases M. Antonieta Valenzuela, Luis Cartier, Aron D. Mosnaim, Marion E. Wolf, Ana Maria Kettlun, Lucia Collados, Lorena Garcia Chapter 9 Neuropeptide Processing Mathias Hallberg, Pierre Le Greves and Fred Nyberg Chapter 10 Proteases and Neuronal Plasticity John W. Wright and Joseph W. Harding Chapter 11 Serine Proteases and Neuronal Plasticity in vivo Nobuko Mataga and Takao K. Hensch Chapter 12 Proteases and Synaptic Activity Hiroshi Nakanishi Chapter 13 Role of Proteinase-Activated Receptors in Brain Function Barry W. Festoff Chapter14 Matrixmetalloproteinases and Neuroinflammation in Multiple Sclerosis Corey C. Ford and Gary W. Rosenberg Index"Jacket Description/Back: In all organs of the body proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer s, Parkinson s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumour progression. Proteases in the Brain brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes. Proteases in the Brain reviews the role and regulation of proteases in Alzheimer s disease brain ischemia and traumatic brain injury human glioma inflammatory and infectious diseases of the central nervous system metabolism of the prion protein modulating synaptic activity multiple sclerosis neuronal plasticity and memory consolidation Parkinson s disease processing, conversion and inactivation of neuropeptides. Proteases in the Brain is a timely and useful source of information both for those well versed in the role of proteases in the brain and for those who are beginning to realize the important role of this family of enzymes in brain function and dysfunction."Publisher Marketing: In all organs of the body, proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer s, Parkinson s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumor progression. Proteases in the Brain brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes. Proteases in the Brain reviews the role and regulation of proteases in, Alzheimer s disease, brain ischemia and traumatic brain injury, human glioma, inflammatory and infectious diseases of the central nervous system, metabolism of the prion protein, modulating synaptic activity, multiple sclerosis, neuronal plasticity and memory consolidation, Parkinson s disease, processing, conversion and inactivation of neuropeptides. Proteases in the Brain is a timely and useful source of information both for those well-versed in the role of proteases in the brain, and for those who are beginning to realize the important role of this family of enzymes in brain function and dysfunction."

Contributor Bio:  Lendeckel, Uwe Uwe Lendeckel is a Reader at the Institute of Experimental InternalMedicine at the Otto-von-Guericke University of Magdeburg, Germany. After his study of pharmacology and toxicology he received his Ph. D inbiochemistry in 1990 from the Ernst-Moritz-Arndt University ofGreifswald. His thesis on the "expression of the pro-opiomelanocortingene in rat Islets of Langerhans and other tissues" stimulated hisinterest in the neuro-immunological cross-talk and the regulatoryroles of cell surface proteases therein. In 1989 he joined theectopeptidase research group at the University of Magdeburg and sincethen continues to study regulation of expression and the function of Tcell ectopeptidases in the normal and pathological immune response,with special focus on the membrane alanyl-aminopeptidase. He haspublished over 40 research papers. Contributor Bio:  Hooper, Nigel M Nigel Hooper is Professor of Biochemistry in the School ofBiochemistry and Molecular Biology at the University of Leeds, UK. Hereceived his Ph. D in 1984 from the University of Leeds with a thesison the "Metabolism of Neuropeptides by Cell-surface Peptidases" whichstimulated his interest in proteases and paved the way for much of hissubsequent research. He currently co-leads the Proteolysis ResearchGroup at Leeds and among other topics, continues to study thestructure and function of several cell-surface proteases, with aparticular interest in their mode of attachment to the membrane. Hehas published over 90 research papers, edited 4 books and co-authoredthe widely acclaimed undergraduate textbook Instant NotesBiochemistry.