Uwe Lendeckel

Proteases in Gastrointestinal Tissues - Proteases in Biology and Disease Uwe Lendeckel 2006 edition

Marc Notes: Includes bibliographical references and index. Table of Contents: Contributing Authors Preface Chapter 1 Protease-Activated Receptors in Gastrointestinal Function and Disease Nigel W. Bunnett and Graeme S. Cottrell Chapter 2 Matrix Metalloproteinases in Gastric Cancer Nikhil I. Khushalani and Nithya Ramnath Chapter 3 Proteases in Helicobacter pylori-Mediated Diseases Thomas Wex, Michael Zack, and Peter Malfertheiner Chapter 4 Proteases in Pancreatic Disease Avinash Sewpaul, Jeremy J. French, and Richard M. Charnley Chapter 5 PAR in the Pathogenesis of Pain in Pancreatic Disease Pankaj J. Pasricha Chapter 6 Importance of the Local Renin-Angiotensin System in Pancreatic Disease Po Sing Leung Chapter 7 Hepatitis C Viral Proteases And Inhibitors Mingjun Huang, Avinash Phadke and Atul Agarwal Chapter 8 Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis Yao Hong Wie Chapter 9 Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation Hein W. Verspaget, Johan P. Kuyvenhoven, Cornelis F. M. Sier, Bart van Hoek Chapter 10 MMPs and ADAMs in Inflammatory Bowel Disease Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Anna Parfieniuk, Anna Moniuszko Chapter 11 Chemokines and Matrix Metalloproteinases in Colorectal Cancer Gayle G. Vaday and Stanley Zucker Chapter 12 Angiotensin-Converting Enzyme (ACE) in Gut Inflammation Fernando Magro Chapter 13 Intestinal Apical Protein Transport in Health and Disease Stephan von Horsten, Michael Krahn, Nadine Frerker, Anja Gemeinhardt, Dennis Schwab, Silvia Slesiona, Hassan Naim, and Marwan Alfalah Index"Publisher Marketing: This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections. In addition, changes in the localization, abundance or activity of proteases may serve as informative diagnostic or prognostic markers. This volume focuses on stomach, gut, pancreas, and liver and highlights the role of proteases in normal physiology and disease processes involving these tissues. The first chapter by Nigel W. Bunnett and Graeme S. Cottrell reviews the current knowledge about the protease-activated receptors (PARs) in gastrointestinal tissues. Starting with the mechanisms of activation, signal transduction, and regulation of PAR, their role in controlling gastrointestinal functions and the possible involvement in gastrointestinal diseases are summarized. In Chapter 2, Nikhil I. Khushalani and Nithya Ramnath review the role of matrix metalloproteases (MMPs) and their natural inhibitors, TIMPs, in different types of gastric cancer.

Contributor Bio:  Lendeckel, Uwe Uwe Lendeckel is a Reader at the Institute of Experimental InternalMedicine at the Otto-von-Guericke University of Magdeburg, Germany. After his study of pharmacology and toxicology he received his Ph. D inbiochemistry in 1990 from the Ernst-Moritz-Arndt University ofGreifswald. His thesis on the "expression of the pro-opiomelanocortingene in rat Islets of Langerhans and other tissues" stimulated hisinterest in the neuro-immunological cross-talk and the regulatoryroles of cell surface proteases therein. In 1989 he joined theectopeptidase research group at the University of Magdeburg and sincethen continues to study regulation of expression and the function of Tcell ectopeptidases in the normal and pathological immune response,with special focus on the membrane alanyl-aminopeptidase. He haspublished over 40 research papers. Contributor Bio:  Hooper, Nigel M Nigel Hooper is Professor of Biochemistry in the School ofBiochemistry and Molecular Biology at the University of Leeds, UK. Hereceived his Ph. D in 1984 from the University of Leeds with a thesison the "Metabolism of Neuropeptides by Cell-surface Peptidases" whichstimulated his interest in proteases and paved the way for much of hissubsequent research. He currently co-leads the Proteolysis ResearchGroup at Leeds and among other topics, continues to study thestructure and function of several cell-surface proteases, with aparticular interest in their mode of attachment to the membrane. Hehas published over 90 research papers, edited 4 books and co-authoredthe widely acclaimed undergraduate textbook Instant NotesBiochemistry.